With Ubuntu 16.10 and my AMD R9 380X video adapter, I'm able to install AMDGPU-PRO and the Vulkan SDK without problem.  Just like in the old days of fglrx, the packages are available in the Yakkety repo.

Not so with my 16.04 installation, which is my daily driver.  To make AMDGPU-PRO and the Vulkan SDK work there, I had to first bring in the 4.8 kernel.  Then I used the AMDGPU-PRO and Vulkan SDK downloads and instructions you can find here to install.

Pretty painless. 

Just to be sure, I uninstalled and reinstalled Boinc.  I chose SETI@Home, since I have been working on that.  I fired it up and, no fuss, it started running -- not only on the AMD FX 8350 Black CPU, but also on the GPU!  SETI@Home does not have an indicator that it is an ATI GPU project.  It didn't work with the GPU before with fglrx and my R9 290X.  But it does work now and I didn't even have to worry about any settings.

The change in work being done is astounding.  The GPU itself is doing roughly 5 times the work the CPU was doing alone.  As a result, my daily production is roughly 6 times what it was.

Here's a little screen shot of a part of my conky, indicating how much load was being put on the GPU by BOINC at that instant.  The temp has been holding steady at 61.0 to 62.0.  That's inside a Fractal Design Define R5, so the fan noise is almost inaudible.

So, a bit of fun.  AMDGPU-Pro is working fine with the Vulkan SDK on Xenial.  I did, however, have to upgrade the kernel. 

For those of you who follow the Ubuntu Forums, I've started to answer some questions about AMDGPU and AMDGPU-PRO there.  I've also started two Community Help pages, one each for AMDGPU and AMDGPU-PRO.  I'll try to start getting those fleshed out as I have time.

Legal Disclaimer:  I am not an Ubuntu apologist, but I do use Ubuntu and Kubuntu.  I am not a Fedora apologist, but I do use Fedora.  I am not a Windows apologist, but I do use Windows.  I'm not a FOSS apologist, but I use FOSS tools when I can and when they fit the job at hand.  I don't find any sense in a religious affiliation with tools and operating systems.  That's just asinine.